EPID-09. AGE-STRATIFIED SURVIVAL ANALYSES OF CO-MORBIDITIES IN PATIENTS WITH GRADE IV GLIOMAS

Abstract Glioblastomas are the most common primary malignant brain tumor in adults. Subject age is a strong prognostic factor for survival. We performed co-morbidity analysis of younger vs. older (greater than 65 years) adults with grade IV gliomas (GIV) to understand inherent differences that vary subject age. Electronic health records 1,208 GIV patients were collected at single center between 1/1/2000 and 9/8/2021 used construct multivariable time-dependent cox model examined intra-cohort hazards associated 33 measures related symptoms. The date diagnosis was identified as start time, death define event time. Patients alive or lost follow-up censored last recorded date. Survival time calculated difference censorship. stratified by IDH MGMT promoter methylation status when available. Younger experienced greater hazard with: limitations movement (1.88 [1.46, 2.43] ****), gait (1.72 [1.17, 2.52] **), weakness (1.96 [1.26, 3.06] seizures (1.28 [1.04, 1.58] *), epilepsy (1.47 [1.09, 1.99] anxiety disorders (2.37 [1.44, 3.92], **). Older an increased confusion altered mental (4.3 [2.08, 8.89], ****). Both groups increases eye/visual systems plegia. These data indicate novel comorbid enrichments varying that, from mechanistic perspective, may be better why survive significantly less counterparts.